A good portion of these syntheses should be saved for the end of the playthrough, as many mid-tier synthesis items can be very useful. The first playthrough will focus on completing all Tier 5 syntheses, as well as most of the Tier 4 and 3 syntheses.
Only possible by fusing two Tier 1 items together. These are items that are created though a single synthesis. These are base items that you purchase in the shop or find as mission rewards, but that are not able to fuse with anything. There are 6 tiers of items in the game, relating to how you obtain them and whether they can be used to fuse others. To help alleviate such troubles, this article will break down some of the details so that you can better plan your synthesises effectively. Simple concept, but it requires quite a bit of trial and error to find out what synthesises to prioritize for the average new player. As expected, item synthesis crams two items together to make a new one.